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KMID : 0360120100320010023
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Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
2010 Volume.32 No. 1 p.23 ~ p.26
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Effects of Hypoxia on the Formation of Osteoclast
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Sim Hye-Young
Jung Da-Un
Chae Chang-Hoon
Lee Young
Jang Eun-Sik
Choi Mee-Ra
Hong Soon-Min
Park Jun-Woo
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Abstract
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The vascular changes in periodontal tissues cause local hypoxia which seems to affect the periodontal tissue cells. Abrupt changes in oxygen availability within the periodontium have been suggested to have a regulatory role in alveolar bone remodeling during tooth movement, bone growth or fracture healing. The purpose of this study was to study the effects of hypoxia on formation of osteoclast responsible for bone resorption, in vitro. Primary mouse bone marrow cells were cultured in normoxic (20% O2) and hypoxic (1% O2) conditions and assayed for cellular proliferation. The results obtained were as follows:
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KEYWORD
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Osteoclast, Hypoxia
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